Vorticity for the Assessment of Right Ventricular Diastolic Dysfunction Using 4D Flow CMR
Thursday, September 21, 2017;
358 Willard Bldg
Speaker: Jean Hertzberg from Dept. Mechanical Engineering University of Colorado Boulder
Right ventricular diastolic dysfunction (RVDD) may represent a precursor to systolic dysfunction and is an important prognostic indicator in pulmonary arterial hypertension (PAH). RV vortex rings have been observed in healthy subjects, but their significance in RV dysfunction is unknown. Vorticity, the local spinning motion of an element of fluid, is expected to be a sensitive measure of right heart cardiac fluid dynamics, and we hypothesize that it correlates with other indices of RVDD. Thirteen (13) subjects with right heart catheterization-proven PAH and 10 age-matched normal controls underwent same-day 4D flow CMR and echocardiography. RV and left ventricular (LV) echocardiographic parameters were assessed using trans-tricuspid valve (TV) and mitral valve (MV) E, A, and e’ velocities as well as E/A ratios. RV and right atrial (RA) integrated mean vorticities were calculated for E and A wave filling periods using anti-aliased and noise-corrected 4D flow datasets. Our initial study of volume-integrated RA and RV vorticities indicates a significant correlation with both RV and LV echo-derived diastolic dysfunction markers. Ongoing investigations involve detailed analyses of atrial and ventricular flow and vorticity fields, and their relationships to specific anatomical features including valve leaflets, trabeculae and papillary muscles. A deeper understanding of the physics is a prerequisite to identification of specific features that can be linked to specific pathologies, and lead to improved diagnoses and treatments. This talk will present an overview of our subject cohort and workflow, and an in-depth visual tour of fluid dynamics in two subjects, one normal and one RVDD patient.
Dr. Hertzberg is an Associate Professor of Mechanical Engineering at CU-Boulder. She teaches graduate and undergraduate courses in measurement techniques, thermodynamics, fluid mechanics, heat transfer, design and computer tools. She has pioneered a spectacular course on the art and physics of flow visualization, and is conducting research on the impact of the course with respect to visual perception and educational outcomes. Her disciplinary research centers around pulsatile, vortex dominated flows with applications in both combustion and bio-fluid dynamics. She is also interested in a variety of flow field measurement techniques. Current projects include velocity and vorticity in human cardiac ventricles and large vessels, and co-hosting the American Physical Society Division of Fluid Dynamics Annual Meeting in Denver, November 2017.
Hosted by: Laura Pauley, Fluid Dynamics Research Consortium
Teaching to Promote a Growth Mindset
Friday, September 22, 2017;
9:00 - 10:30 am
202 Hammond Building (Stavely Conference Room)
Speaker: Sarah Zappe from Penn State University
Join us for a special Leonhard Center breakfast workshop, “Teaching to Promote a Growth Mindset” which will be held Friday, September 22 from 9 to 10:30 a.m. in 202 Hammond (Stavely Conference Room). The purpose of the workshop is to help instructors understand the differences between fixed versus growth mindset and how instructional approaches can promote one or the other.
Originating with psychologist Carol Dweck, individuals with a fixed mindset believe that a specific ability or intelligence is innate and fixed. In contrast, individuals with a growth mindset believe that ability or intelligence can be improved with training and practice. Through implicit and explicit messages to their students, instructors may inadvertently trigger students to approach tasks with a fixed mindset. The interactive session will focus on common messages and strategies that will help students to approach tasks in a class with a growth mindset.
Hosted by: Sarah Zappe, The Leonhard Center