Upcoming Seminars

Week of November 13Week of November 20Week of November 27Week of December 4

Biomedical Engineering

Vascular Grafts and Tubular Heart Valves that Heal and Grow

Thursday, November 16, 2017; 12:05 PM - 1:20 PM
5 Health & Human Development Building
Speaker: Dr. Robert Tranquillo from University of Minnesota

We have developed a novel tissue-engineered vascular graft, which is allogeneic upon a decellularization performed prior to implantation and thus “off-the-shelf.” It is grown from remodeling of dermal fibroblasts entrapped in a sacrificial fibrin gel into tissue tube that is then decellularized using sequential detergent treatments. The resulting cell-produced matrix tube possesses physiological strength, compliance, and alignment (circumferential). We have shown promising results implanting these tubes into the sheep femoral position at 6 months, including complete recellularization and positive remodeling) without mineralization, dilatation, or immune response (Syedain et al, 2015). Similar results have recently been obtained in a pivotal preclinical model as an AV graft for 6 months, including periodic access with a dialysis needle (Syedain et al, 2017). We have also recently shown somatic growth of these tubes implanted into the pulmonary of young lambs for almost 50 weeks, through adulthood (Syedain et al, 2016). Using the concept of a tubular heart valve, where the tube collapses inward with back-pressure between 3 equi-spaced constraints placed around the periphery to create one-way valve action, we have reported unprecedented results implanting valves fabricated from these tubes mounted on 3-pronged crown frames into the sheep aortic position for 6 months (Syedain et al, 2015). We have also used the principle of a tubular heart valve to innovate a tubular pediatric heart valve based on attaching two tubes together with degradable suture to provide the constraints (Reimer et al, 2015) and developed initial experience in a young lamb model (Reimer et al, 2016). Some of the science and engineering extending back 25 years and underlying these recent translation efforts will be included, particularly how cells sense fibril alignment, which results in contact guidance and the circumferential alignment of the tissue tube.

Hosted by: Jenna Sieber,  Biomedical Engineering  (jns5431@psu.edu)

Chemical Engineering

Programming Proteins by Deep Sequencing and Design

Tuesday, November 14, 2017; 10:50 - 11:50 am
102 Chemistry
Speaker: Tim Whitehead from Michigan State University

Programming Proteins by Deep Sequencing and Design

Hosted by: Lisa Haines,  Chemical Engineering  (lhaines@engr.psu.edu)

Engineering the Artificial Pancreas

Thursday, November 16, 2017; 10:50 - 11:50 AM
102 Chemistry Building
Speaker: Francis J. Doyle, III from Harvard John A. Paulson School of Engineering & Applied Sciences, Cambridge, MA

Engineering the Artificial Pancreas

Hosted by: Lisa Haines,  Chemical Engineering  (lhaines@engr.psu.edu)

Engineering Science and Mechanics

Developing Fundamental Process-Structure-Property Relationships for Size and Geometry in Directed Energy Deposition Processes

Wednesday, November 15, 2017; 3:35 pm
114 EES Building
Speaker: Todd A Palmer from Dept of Engineering Science and Mechanics, PSU

Additive manufacturing (AM) processes utilizing high energy density laser and electron beam energy sources are used to fabricate a range of metallic components with varying complexity and sizes. As the sizes of fabricated components increase, changes in the processing conditions impact the complex thermal histories experienced at each location and the corresponding process-structure-property relationships. Recent work with Ti-6Al-4V alloys fabricated using directed energy deposition (DED) processes has shown that changes in geometry result in statistically significant differences in mechanical properties. As sizes increase to accommodate larger structural components, changes in processing conditions, to include higher deposition rates as well as longer dwell times, produce unexpected challenges in the prediction of microstructures, mechanical properties, as well as residual stress states and distortion. The development of fundamental scaling relationships that can be used to predict the mechanical properties is an important area of research as part geometries increase in both size and complexity. A review of recent work in this area and a path for the integration of these scaling relationships in future modeling and simulation tools are provided.

Hosted by: Dr. Akhlesh Lakhtakia,  Engineering Science and Mechanics  (axl4@psu.edu)

Fluid Dynamics Research Consortium

Improving CFD Robustness and Fidelity Through Output-Based Adaptive Methods

Thursday, November 16, 2017; 9:00 AM
358 Willard Bldg
Speaker: Krzysztof Fidkowski from University of Michigan

Abstract: Computational fluid dynamics has advanced at a rapid pace over the last several decades, driven by improvements in both hardware and algorithms.  These advancements have made possible large-scale fluid dynamics simulations, with detailed physics and over intricate geometries.  However, as simulations become more complex, so does the task of ensuring accuracy of the results.  Expert practitioners can no longer assess accuracy visually due to the complexity of flow fields, and best-practice meshing and verification guidelines may not apply to the analysis of novel configurations.  This presentation introduces output-based methods for addressing this situation: the process of estimating errors and improving fidelity becomes automated, so that robustness of the solution process can be vastly improved.  Output-based methods rely on the solution of an auxiliary adjoint problem, which has already seen application to shape optimization and data assimilation.  We explore many uses of the adjoint solution for optimizing computations relevant to aerospace engineering, including steady-state mesh refinement, unstructured mesh optimization, adapting in space and time for unsteady simulations, and adapting both the mesh and approximation order in high-order methods.  We also present new results from ongoing projects in improving efficiency of the calculation of the error estimates, and in combining mesh optimization with shape optimization. Bio: Krzysztof Fidkowski is an Associate Professor in the Aerospace Engineering Department at the University of Michigan.  He received his undergraduate degrees in Aerospace Engineering and Physics, and his S.M. and Ph.D. degrees in Aerospace Engineering from the Massachusetts Institute of Technology.  His primary research field is in algorithmic development for computational fluid dynamics, specifically in the use of adjoint methods for numerical error estimation, mesh adaptation, and uncertainty quantification.


Hosted by: David Williams,  Fluid Dynamics Research Consortium  (dmw72@psu.edu)

Mechanical and Nuclear Engineering

Full Core Modeling with Coupled Monte-Carlo Codes

Thursday, November 16, 2017; 4:00 - 5:30 pm
22 Deike Building
Speaker: Dan Kotlyar from Georgia Tech

Modeling advanced reactor designs represents a significant challenge to the conventional reactor analysis methods. Monte Carlo (MC) method is perceived as an ideal alternative to accurately model various advanced reactor systems due to the capability of simulating complex core geometries.  The advances in computer technology are gradually changing the reactor analysis modeling environment. As a result, MC neutron transport codes are increasingly used as a standard calculation tool in reactor calculations. It is even becoming practical to couple MC neutron transport calculations with depletion and thermal hydraulic (TH) feedbacks to extend the range of applications even further. Many MC-burnup coupling schemes have been developed. This seminar will present coupling methods used in various MC based reactor analysis systems. In particular, the effect of different burnup-TH coupling schemes on the numerical stability and accuracy of coupled MC calculations will be presented. The seminar will focus on the latest development and possible future research pathways.

Hosted by: Karen Thole,  Mechanical Engineering  (amb52@psu.edu)

Mechanical Engineering

Recent Progress in Multiphase Flow CFD: Numerics, Modeling, Discovery and Applications

Tuesday, November 14, 2017; 4:35 - 5:35 pm
135 Reber Building
Speaker: Robert Kunz from Penn State

Multiphase flows are important in a vast number of engineered and natural systems. Their physical complexity leads to attendant modeling, numerics and analysis challenges generally exceeding those encountered in single phase systems. In this talk, an overview of the speaker’s research in this area is made: · numerics including high density ratio system preconditioning, Eulerian n-fluid algorithms, interface capturing, · physical modeling including free surface flows, boiling, cavitation, deposition, film flows, and, · applications including developed cavitation for turbomachinery, microbubble drag reduction, aircraft icing, boiling heat exchanger flows, particle transport/deposition in the human lung, and, microscale biological cell/organism transport.

Hosted by: Karen Thole,  Mechanical Engineering  (amb52@psu.edu)

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