Photo of Jian Yang

Jian Yang

Professor of Biomedical Engineering


  • Biomedical Engineering

W340 Millennium Science Complex


Personal or Departmental Website

Research Areas:

Cell Signaling and Cancer; Nanomedicine and Drug Delivery; Tissue Engineering and Regenerative Medicine

Interest Areas:

Biomaterials, Tissue engineering, Drug delivery, Medical devices.




  • BS, Chemistry, Nanchang University, 1996
  • MS, Physical Chemistry, Nanchang University, 1999
  • PhD, Biomedical Polymers, Institute of Chemistry, Chinese Academy of Sciences, 2002


Journal Articles

  • Dingbowen Wang, Michelle Kuzma, Cheng Dong, Cheng Dong, Cheng Dong, Zhiwen Liu and Jian Yang, 2021, "Phototherapy and Optical Waveguides for the Treatment of Infection", Advanced Drug Delivery Reviews, 179, pp. 114036
  • Jinshan Guo, Xinggui Tian, Denghui Xie, Kevin Rahn, Ethan Gerhard, Michelle Laurel Kuzma, Dongfang Zhou, Cheng Dong, Xiaochun Bai, Zhihui Lu, others and Jian Yang, 2020, "Bone Composites: Citrate-Based Tannin-Bridged Bone Composites for Lumbar Fusion (Adv. Funct. Mater. 27/2020)", Advanced Functional Materials, 30, (27), pp. 2070179
  • Jinshan Guo, Xinggui Tian, Denghui Xie, Kevin Rahn, Ethan Gerhard, Michelle Laurel Kuzma, Dongfang Zhou, Cheng Dong, Xiaochun Bai, Zhihui Lu and Jian Yang, 2020, "Citrate-Based Tannin-Bridged Bone Composites for Lumbar Fusion", Advanced Functional Materials, pp. 2002438
  • Qing Li, Limei Li, Mali Yu, Meng Zheng, Yao Li, Jian Yang, Min Dai, Lianmei Zhong, Lin Sun and Di Lu, 2020, "Elastomeric polyurethane porous film functionalized with gastrodin for peripheral nerve regeneration", Journal of Biomedical Materials Research Part A
  • Gloria B Kim, Virginia Aragon-Sanabria, Lauren Randolph, Hali Jiang, Joshua A Reynolds, Becky S Webb, Achuthamangalam Madhankumar, Xiaojun Lian, James R Connor, Jian Yang and others, 2020, "High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma", Bioactive Materials, 5, (3), pp. 624--635
  • Xili Lu, Sanjun Shi, Hanmei Li, Ethan Gerhard, Zhihui Lu, Xinyu Tan, Wenliang Li, Kevin M Rahn, Denghui Xie, Guodong Xu and Jian Yang, 2020, "Magnesium oxide-crosslinked low-swelling citrate-based mussel-inspired tissue adhesives", Biomaterials, 232, pp. 119719
  • Meng Zheng, Jiazhi Guo, Qing Li, Jian Yang, Yi Han, Hongcai Yang, Mali Yu, Lianmei Zhong, Di Lu, Limei Li and others, 2020, "Syntheses and characterization of anti-thrombotic and anti-oxidative Gastrodin-modified polyurethane for vascular tissue engineering", Bioactive Materials, 6, (2), pp. 404--419
  • Nikhil Pandey, Jyothi U Menon, Masaya Takahashi, Jer-Tsong Hsieh, Jian Yang, Kytai T Nguyen and Aniket S Wadajkar, 2020, "Thermo-responsive Fluorescent Nanoparticles for Multimodal Imaging and Treatment of Cancers", Nanotheranostics, 4, (1), pp. 1
  • J Lu, Huanan Zhang, Daolu Cai, C Zeng, P Lai, Y Shao, H Fang, D Li, J Ouyang, C Zhao, D Xie, B Huang, Jian Yang, Y Jiang and X Bai, 2018, "Positive-feedback regulation of subchondral H-type vessel formation by chondrocyte promotes osteoarthritis development in mice.", Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • Jian Yang, 2018, "Citrate-based fluorescent biomaterials", Advanced Healthcare Materials
  • Jian Yang, 2018, "Exosome Release Is Regulated by mTORC1", Advanced Science
  • C Zhang, J P Kim, M Creer, Jian Yang and Zhiwen Liu, 2017, "A smartphone-based chloridometer for point-of-care diagnostics of cystic fibrosis.", Biosensors & bioelectronics, 97, pp. 164-168
  • D Shan, C Zhang, S Kalaba, N Mehta, G B Kim, Zhiwen Liu and Jian Yang, 2017, "Flexible biodegradable citrate-based polymeric step-index optical fiber.", Biomaterials, 143, pp. 142-148
  • E M Gerhard, Wen-Li Wang, C Li, Jinshan Guo, Ibrahim Ozbolat, K M Rahn, A D Armstrong, J Xia, G Qian and Jian Yang, 2017, "Design strategies and applications of nacre-based biomaterials.", Acta biomaterialia, 54, pp. 21-34
  • Jinai Sun, L Jiang, Y Lin, E M Gerhard, X Jiang, L Li, Jian Yang and Zhuojun Gu, 2017, "Enhanced anticancer efficacy of paclitaxel through multistage tumor-targeting liposomes modified with RGD and KLA peptides.", International journal of nanomedicine, 12, pp. 1517-1537
  • J P Kim, Z Xie, M Creer, Zhiwen Liu and Jian Yang, 2017, "Citrate-based fluorescent materials for low-cost chloride sensing in the diagnosis of Cystic Fibrosis.", Chemical science, 8, (1), pp. 550-558
  • Jinshan Guo, G B Kim, D Shan, J P Kim, J Hu, Wen-Li Wang, F G Hamad, G Qian, E B Rizk and Jian Yang, 2017, "Click chemistry improved wet adhesion strength of mussel-inspired citrate-based antimicrobial bioadhesives.", Biomaterials, 112, pp. 275-286
  • Jian Yang, 2017, "Self-assembly of Smart Multifunctional Hybrid Compartments with Programmable Bioactivity", Chemistry of Materials, 29, pp. 2081-2089
  • Jian Yang, 2017, "Highly photostable nanogels for fluorescence-based theranostics", Bioactive Materials
  • Jian Yang, 2017, "Ionic Colloidal Molding as a Biomimetic Scaffolding Strategy for Uniform Bone Tissue Regeneration", Advanced Materials, 29, pp. 1605546-1605555
  • Z Xie, Y Su, G B Kim, E Selvi, C Ma, V Aragon-Sanabria, J T Hsieh, Cheng Dong and Jian Yang, 2017, "Immune Cell-Mediated Biodegradable Theranostic Nanoparticles for Melanoma Targeting and Drug Delivery.", Small (Weinheim an der Bergstrasse, Germany)
  • J Li, Y Tian, D Shan, A Gong, L Zeng, W Ren, L Xiang, E Gerhard, J Zhao, Jian Yang and A Wu, 2017, "Neuropeptide Y Y1 receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging.", Biomaterials, 116, pp. 106-117
  • Z Xie, J P Kim, Q Cai, Y Zhang, Jinshan Guo, R S Dhami, L Li, B Kong, Y Su, K A Schug and Jian Yang, 2017, "Synthesis and characterization of citrate-based fluorescent small molecules and biodegradable polymers.", Acta biomaterialia, 50, pp. 361-369
  • D Zhou, Jinshan Guo, G B Kim, J Li, Xiaodong Chen, Jian Yang and Y Huang, 2016, "Simultaneously Photo-Cleavable and Activatable Prodrug-Backboned Block Copolymer Micelles for Precise Anticancer Drug Delivery.", Advanced healthcare materials, 5, (19), pp. 2493-2499
  • J P Lata, F Guo, Jinshan Guo, P H Huang, Jian Yang and Jun Huang, 2016, "Surface Acoustic Waves Grant Superior Spatial Control of Cells Embedded in Hydrogel Fibers.", Advanced materials (Deerfield Beach, Fla.), 28, (39), pp. 8632-8638
  • S Kalaba, E Gerhard, J S Winder, E M Pauli, R S Haluck and Jian Yang, 2016, "Design Strategies and Applications of Biomaterials and Devices for Hernia Repair.", Bioactive materials, 1, (1), pp. 2-17
  • Jinshan Guo, Wen-Li Wang, J Hu, D Xie, E Gerhard, M Nisic, D Shan, G Qian, Siyang Zheng and Jian Yang, 2016, "Synthesis and characterization of anti-bacterial and anti-fungal citrate-based mussel-inspired bioadhesives.", Biomaterials, 85, pp. 204-17
  • F Guo, Z Mao, Y Chen, Z Xie, J P Lata, P Li, L Ren, Jude Liu, Jian Yang, M Dao, S Suresh and Jun Huang, 2016, "Three-dimensional manipulation of single cells using surface acoustic waves.", Proceedings of the National Academy of Sciences of the United States of America, 113, (6), pp. 1522-7
  • J Hu, Jinshan Guo, Z Xie, D Shan, E Gerhard, G Qian and Jian Yang, 2016, "Fluorescence imaging enabled poly(lactide-co-glycolide).", Acta biomaterialia, 29, pp. 307-19
  • Jian Yang, 2016, "Click crosslinking improved waterborne polymers for environment-friendly coatings and adhesives", ACS Applied Materials & Interfaces, (8), pp. 17499-17510
  • Jian Yang, 2016, "Design Strategies and Applications of Biomaterials and Devices for Hernia Repair", Bioactive Materials, 1, pp. 2-17
  • Jian Yang, 2016, "Constrained Hierarchical Modeling of Degradation Data in Tissue-engineered Scaffold Fabrication", IIE Transactions, 48, pp. 16-33
  • Z Xie, N V Aphale, T D Kadapure, A S Wadajkar, S Orr, D Gyawali, G Qian, K T Nguyen and Jian Yang, 2015, "Design of antimicrobial peptides conjugated biodegradable citric acid derived hydrogels for wound healing.", Journal of biomedical materials research. Part A, 103, (12), pp. 3907-18
  • J Tang, Jinshan Guo, Z Li, Chengwu Yang, D Xie, Jin Chen, S Li, S Li, G B Kim, X Bai, Zhihua Zhang and Jian Yang, 2015, "Fast degradable citrate-based bone scaffold promotes spinal fusion.", Journal of materials chemistry. B, Materials for biology and medicine, 3, (27), pp. 5569-5576
  • R T Tran, Jian Yang and G A Ameer, 2015, "Citrate-Based Biomaterials and Their Applications in Regenerative Engineering.", Annual review of materials research, 45, pp. 277-310
  • D Xie, Jinshan Guo, M Mehdizadeh, R T Tran, R Chen, Dongxiao Sun, G Qian, Dezhe Jin, X Bai and Jian Yang, 2015, "Development of Injectable Citrate-Based Bioadhesive Bone Implants.", Journal of materials chemistry. B, Materials for biology and medicine, 3, pp. 387-398
  • Y Su, Z Xie, G B Kim, Cheng Dong and Jian Yang, 2015, "Design strategies and applications of circulating cell-mediated drug delivery systems.", ACS biomaterials science & engineering, 1, (4), pp. 201-217
  • Dongxiao Sun, Y Chen, R T Tran, Susan H Xu, D Xie, C Jia, Y Wang, Yao Guo, Zhihua Zhang, Jinshan Guo, Jian Yang, Dezhe Jin and X Bai, 2014, "Citric acid-based hydroxyapatite composite scaffolds enhance calvarial regeneration.", Scientific reports, 4, pp. 6912
  • R T Tran, L Wang, C Zhang, M Huang, W Tang, C Zhang, Zhihua Zhang, Dezhe Jin, B Banik, Justin Lee Brown, Z Xie, X Bai and Jian Yang, 2014, "Synthesis and characterization of biomimetic citrate-based biodegradable composites.", Journal of biomedical materials research. Part A, 102, (8), pp. 2521-32
  • R T Tran, W M Choy, H Cao, I Qattan, J C Chiao, W Y Ip, K W Yeung and Jian Yang, 2014, "Fabrication and characterization of biomimetic multichanneled crosslinked-urethane-doped polyester tissue engineered nerve guides.", Journal of biomedical materials research. Part A, 102, (8), pp. 2793-804
  • Z Xie, Y Zhang, L Liu, H Weng, Rebecca Mason, L Tang, K T Nguyen, J T Hsieh and Jian Yang, 2014, "Development of intrinsically photoluminescent and photostable polylactones.", Advanced materials (Deerfield Beach, Fla.), 26, (26), pp. 4491-6
  • L C Su, Z Xie, Y Zhang, K T Nguyen and Jian Yang, 2014, "Study on the Antimicrobial Properties of Citrate-Based Biodegradable Polymers.", Frontiers in bioengineering and biotechnology, 2, pp. 23
  • Jinshan Guo, Z Xie, R T Tran, D Xie, Dezhe Jin, X Bai and Jian Yang, 2014, "Click chemistry plays a dual role in biodegradable polymer design.", Advanced materials (Deerfield Beach, Fla.), 26, (12), pp. 1906-11
  • Z Xie, C B Paras, H Weng, P Punnakitikashem, L C Su, K Vu, L Tang, Jian Yang and K T Nguyen, 2013, "Dual growth factor releasing multi-functional nanofibers for wound healing.", Acta biomaterialia, 9, (12), pp. 9351-9
  • Y Zhang, R T Tran, I S Qattan, Y T Tsai, L Tang, C Liu and Jian Yang, 2013, "Fluorescence imaging enabled urethane-doped citrate-based biodegradable elastomers.", Biomaterials, 34, (16), pp. 4048-56
  • A S Wadajkar, J U Menon, T Kadapure, R T Tran, Jian Yang and K T Nguyen, 2013, "Design and Application of Magnetic-based Theranostic Nanoparticle Systems.", Recent patents on biomedical engineering, 6, (1), pp. 47-57
  • M Mehdizadeh and Jian Yang, 2013, "Design strategies and applications of tissue bioadhesives.", Macromolecular bioscience, 13, (3), pp. 271-88
  • Y Zhang and Jian Yang, 2013, "Design Strategies for Fluorescent Biodegradable Polymeric Biomaterials.", Journal of materials chemistry. B, Materials for biology and medicine, 1, (2), pp. 132-148
  • D Gyawali, P Nair, H K Kim and Jian Yang, 2013, "Citrate-based Biodegradable Injectable hydrogel Composites for Orthopedic Applications.", Biomaterials science, 1, (1), pp. 52-64
  • M Mehdizadeh, H Weng, D Gyawali, L Tang and Jian Yang, 2012, "Injectable citrate-based mussel-inspired tissue bioadhesives with high wet strength for sutureless wound closure.", Biomaterials, 33, (32), pp. 7972-83
  • A S Wadajkar, T Kadapure, Y Zhang, W Cui, K T Nguyen and Jian Yang, 2012, "Dual-imaging enabled cancer-targeting nanoparticles.", Advanced healthcare materials, 1, (4), pp. 450-6
  • R T Tran, M Palmer, S J Tang, T L Abell and Jian Yang, 2012, "Injectable drug-eluting elastomeric polymer: a novel submucosal injection material.", Gastrointestinal endoscopy, 75, (5), pp. 1092-7
  • Y Jiao, D Gyawali, J M Stark, P Akcora, P Nair, R T Tran and Jian Yang, 2012, "A Rheological Study of Biodegradable Injectable PEGMC/HA Composite Scaffolds.", Soft matter, 8, (5), pp. 1499-1507
  • J Dey, R T Tran, J Shen, L Tang and Jian Yang, 2011, "Development and long-term in vivo evaluation of a biodegradable urethane-doped polyester elastomer.", Macromolecular materials and engineering, 296, (12), pp. 1149-1157
  • R T Tran, E Naseri, A Kolasnikov, X Bai and Jian Yang, 2011, "A new generation of sodium chloride porogen for tissue engineering.", Biotechnology and applied biochemistry, 58, (5), pp. 335-44
  • C A Serrano, Y Zhang, Jian Yang and K A Schug, 2011, "Matrix-assisted laser desorption/ionization mass spectrometric analysis of aliphatic biodegradable photoluminescent polymers using new ionic liquid matrices.", Rapid communications in mass spectrometry : RCM, 25, (9), pp. 1152-8
  • Y Zhang, R T Tran, D Gyawali and Jian Yang, 2011, "Development of Photocrosslinkable Urethane-Doped Polyester Elastomers for Soft Tissue Engineering.", International journal of biomaterials research and engineering, 1, (1), pp. 18-31
  • D Gyawali, P Nair, Y Zhang, R T Tran, C Zhang, M Samchukov, M Makarov, H K Kim and Jian Yang, 2010, "Citric acid-derived in situ crosslinkable biodegradable polymers for cell delivery.", Biomaterials, 31, (34), pp. 9092-105
  • J Dey, Heng Xu, K T Nguyen and Jian Yang, 2010, "Crosslinked urethane doped polyester biphasic scaffolds: Potential for in vivo vascular tissue engineering.", Journal of biomedical materials research. Part A, 95, (2), pp. 361-70
  • R T Tran, P Thevenot, Y Zhang, D Gyawali, L Tang and Jian Yang, 2010, "Scaffold Sheet Design Strategy for Soft Tissue Engineering.", Materials, 3, (2), pp. 1375-1389
  • D Gyawali, R T Tran, K J Guleserian, L Tang and Jian Yang, 2010, "Citric-acid-derived photo-cross-linked biodegradable elastomers.", Journal of biomaterials science. Polymer edition, 21, (13), pp. 1761-82
  • J Dey, Heng Xu, J Shen, P Thevenot, S R Gondi, K T Nguyen, B S Sumerlin, L Tang and Jian Yang, 2008, "Development of biodegradable crosslinked urethane-doped polyester elastomers.", Biomaterials, 29, (35), pp. 4637-49
  • P Thevenot, A Nair, J Dey, Jian Yang and L Tang, 2008, "Method to analyze three-dimensional cell distribution and infiltration in degradable scaffolds.", Tissue engineering. Part C, Methods, 14, (4), pp. 319-31
  • Jian Zhang, J Jia, J P Kim, H Shen, F Yang, Qiming Zhang, M Xu, W Bi, X Wang, Jian Yang and Dinghao Wu, , "Ionic Colloidal Molding as a Biomimetic Scaffolding Strategy for Uniform Bone Tissue Regeneration.", Advanced materials (Deerfield Beach, Fla.)
  • Jian Yang, , "Development of tannin-inspired antimicrobial bioadhesives", Acta Biomaterialia, pp. 72:35-44
  • Jian Yang, , "The Critical Chemical and Mechanical Regulation of Folic Acid on Neural Engineering", Biomaterials
  • Jian Yang, , "pH protective Y1 receptor ligand functionalized antiphagocytosis BPLP-WPU micelles for enhanced tumor imaging and therapy with prolonged survival time", Biomaterials
  • Jian Yang, , "Citrate chemistry and biology for biomaterials design", Biomaterials
  • Jian Yang, , "Engineered healing of avascular meniscus tears by stem cell recruitmen", Scientific Reports
  • Jian Yang, , "Development of Citrate-based Dual-Imaging Enabled Biodegradable Electroactive Polymers", Advanced Functional Materials
  • Jian Yang, , "Bone and plasma citrate is reduced in osteoporosis", Bone
  • Jian Yang, , "Polymeric biomaterials for biophotonic applications", Bioactive Materials
  • Jian Yang, , "Chondrocyte mTORC1 activation stimulates miR-483-5p via HDAC4 in osteoarthritis progression", Journal of Cellular Physiology
  • Jian Yang, , "Citrate-based materials fuel human stem cells by metabonegenic regulation", PNAS
  • Jian Yang, , "Nanoparticle eluting-angioplasty balloons to treat cardiovascular diseases", International Journal of Pharmaceutics, 554, pp. 212-223
  • Jian Yang, , "Effect of dose and release rate of CTGF and TGFß3 on avascular meniscus healing", Journal of Orthopaedic Research, 37, (7), pp. 1555-1562
  • Jian Yang, , "Development of Osteopromotive Poly (octamethylene citrate glycerophosphate) (POC-GP) for Enhanced Bone Regeneration", Acta Biomaterialia, 93, pp. 180-191
  • Jian Yang, , "Enabling Biodegradable Functional Biomaterials for the Management of Neurological Disorders", Advanced Drug Delivery Reviews
  • Jian Yang, , "Biomaterials-Based Metabolic Regulation in Regenerative Engineering", Advanced Science, pp. 1900819
  • Jian Yang, , "Photoluminescent polylactone-based theranostic nanoparticles for cardiovascular applications", Front. Bioeng. Biotechnol.,
  • Jian Yang, , "Thermo-responsive Fluorescent Nanoparticles for Multimodal Imaging and Treatment of Cancers", Nanotheranostics, 4, (1), pp. 1-13
  • Jian Yang, , "Magnesium oxide-crosslinked low-swelling citrate-based mussel-inspired tissue adhesives", Biomaterials, 232, pp. 119719
  • Qiong Wei, Jian Yang and Sulin Zhang, , "Actin-ring segment switching drives nonadhesive gap closure", PNAS, 117, (52), pp. 33263-33271


  • Jian Yang and Ethan Gerhard, 2020, "Ion-Crosslinked Polymeric or Oligomeric Compositions"
  • Jian Yang, Jimin Peter Kim and Zhiwei Xie, 2020, "Luminescent compositions and applications thereof"
  • Jian Yang, DONG Cheng and Zhiwei Xie, 2020, "Compositions and methods for targeted delivery of therapeutic and/or diagnostic agents"

Research Projects

Honors and Awards

  • Quality and Reliability Engineering Best Paper Award, IEEE Transaction, 2017
  • Fellow of National Academy of Inventors, National Academy of Inventors, November 2018
  • Fellow of AAAS, American Association for the Advancement of Science (AAAS), 2021
  • Fellow of American Institute of Medical and Biological Engineering (AIMBE), AIMBE, January 2016
  • Standing Member of NIH Study Section - Biomaterials and Biointerface (BMBI), NIH, June 2015
  • Full Member, Sigma Xi, Sigma Xi, The Scientific Research Honor Society, 2022
  • Fellow of Biomedical Engineering Society, Biomedical Engineering Society, July 2020
  • PSEAS Outstanding Research Award, COE, 2018


Service to Penn State:

Service to External Organizations: