Photo of James Mutunga

James Mutunga

Assistant Research Professor

Affiliation(s):

  • School of Engineering Design and Innovation

219B Engineering Design and Innovation Building

jjm7962@psu.edu

814-865-2952

 
 

 

Education

Publications

Journal Articles

  • J M Muema, James Mutunga, M A Obonyo, M N Getahun, R S Mwakubambanya, H M Akala, A C Cheruiyot, R A Yeda, D W Juma, B Andagalu, J L Johnson, A L Roth and J L Bargul, 2023, "Isoliensinine from Cissampelos pariera rhizomes exhibits potential gametocytocidal and anti-malarial activities against Plasmodium falciparum clinical isolates.", Malaria journal, 22, (1), pp. 161
  • A Roberds, C Kifude, J Oyieko, S Ocholla, James Mutunga, D Oullo, C Waga, Z Li, S Luckhart and V A Stewart, 2022, "Longitudinal impact of asymptomatic malaria/HIV-1 co-infection on Plasmodium falciparum gametocyte transcript expression and transmission to Anopheles mosquitoes.", Frontiers in cellular and infection microbiology, 12, pp. 934641
  • J M Muema, J L Bargul, M A Obonyo, S N Njeru, D Matoke-Muhia and James Mutunga, 2022, "Contemporary exploitation of natural products for arthropod-borne pathogen transmission-blocking interventions.", Parasites & vectors, 15, (1), pp. 298
  • J M Muema, J L Bargul, James Mutunga, M A Obonyo, G O Asudi and S N Njeru, 2021, "Neurotoxic Zanthoxylum chalybeum root constituents invoke mosquito larval growth retardation through ecdysteroidogenic CYP450s transcriptional perturbations.", Pesticide biochemistry and physiology, 178, pp. 104912
  • Esther A. Obonyo and James Mutunga, 2021, "A global building network research for advancing healthy and affordable housing", Cities \& Health, 5, (sup1), pp. S166-S169
  • James Mutunga, M Ma, Q H Chen, J A Hartsel, D M Wong, S Ding, M Totrov, P R Carlier and J R Bloomquist, 2019, "Mosquito Acetylcholinesterase as a Target for Novel Phenyl-Substituted Carbamates.", International journal of environmental research and public health, 16, (9)
  • P N Ng'ang'a, James Mutunga, G Oliech and C M Mutero, 2019, "Community knowledge and perceptions on malaria prevention and house screening in Nyabondo, Western Kenya.", BMC public health, 19, (1), pp. 423
  • M Makanda, G Kemunto, L Wamuyu, J Bargul, J Muema and James Mutunga, 2019, "Diversity and Molecular Characterization of Mosquitoes (Diptera: Culicidae) in Selected Ecological Regions in Kenya.", F1000Research, 8, pp. 262
  • B.M. Ogallo, P. Ouma, F.M. Wanjala, D.R. Swale and James Mutunga, 2019, "Optimizing a Gravid Mosquito Resting Box to Enhance Auto-dissemination of Larvicides under Semi-field Conditions in Western Kenya", Journal of Mosquito Research
  • P R Carlier, Q H Chen, A Verma, D M Wong, James Mutunga, J Müller, R Islam, A M Shimozono, F Tong, J Li, M Totrov and J R Bloomquist, 2018, "Select ß- and ?-branched 1-alkylpyrazol-4-yl methylcarbamates exhibit high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase.", Pesticide biochemistry and physiology, 151, pp. 32-39
  • F M Moukam Kakmeni, Guimapi RYA, F T Ndjomatchoua, S A Pedro, James Mutunga and Tonnang HEZ, 2018, "Spatial panorama of malaria prevalence in Africa under climate change and interventions scenarios.", International journal of health geographics, 17, (1), pp. 2
  • M M Quinlan, James Mutunga, A Diabaté, M Namountougou, M B Coulibaly, L Sylla, J Kayondo, V Balyesima, L Clark, M Q Benedict and P Raymond, 2018, "Studies of Transgenic Mosquitoes in Disease-Endemic Countries: Preparation of Containment Facilities.", Vector borne and zoonotic diseases (Larchmont, N.Y.), 18, (1), pp. 21-30
  • M M Quinlan, J Birungi, M B Coulibaly, A Diabaté, L Facchinelli, W R Mukabana, James Mutunga, T Nolan, P Raymond and S F Traoré, 2018, "Containment Studies of Transgenic Mosquitoes in Disease Endemic Countries: The Broad Concept of Facilities Readiness.", Vector borne and zoonotic diseases (Larchmont, N.Y.), 18, (1), pp. 14-20
  • E Ogola, J Villinger, D Mabuka, D Omondi, B Orindi, James Mutunga, V Owino and D K Masiga, 2017, "Composition of Anopheles mosquitoes, their blood-meal hosts, and Plasmodium falciparum infection rates in three islands with disparate bed net coverage in Lake Victoria, Kenya.", Malaria journal, 16, (1), pp. 360
  • J Snetselaar, B N Njiru, B Gachie, P Owigo, R Andriessen, K Glunt, A J Osinga, James Mutunga, M Farenhorst and Knols BGJ, 2017, "Eave tubes for malaria control in Africa: prototyping and evaluation against Anopheles gambiae s.s. and Anopheles arabiensis under semi-field conditions in western Kenya.", Malaria journal, 16, (1), pp. 276
  • J M Muema, S G Nyanjom, James Mutunga, S N Njeru and J L Bargul, 2017, "Green tea proanthocyanidins cause impairment of hormone-regulated larval development and reproductive fitness via repression of juvenile hormone acid methyltransferase, insulin-like peptide and cytochrome P450 genes in Anopheles gambiae sensu stricto.", PloS one, 12, (3), pp. e0173564
  • James Mutunga, Q H Chen, D M Wong, P C Lam, J Li, M M Totrov, A D Gross, P R Carlier and J R Bloomquist, 2016, "Bivalent Carbamates as Novel Control Agents of the Malaria Mosquito, Anopheles gambiae.", Chimia, 70, (10), pp. 704-708
  • J M Muema, J L Bargul, S G Nyanjom, James Mutunga and S N Njeru, 2016, "Potential of Camellia sinensis proanthocyanidins-rich fraction for controlling malaria mosquito populations through disruption of larval development.", Parasites & vectors, 9, (1), pp. 512
  • E Camerino, D M Wong, F Tong, F Körber, A D Gross, R Islam, E Viayna, James Mutunga, J Li, M M Totrov, J R Bloomquist and P R Carlier, 2015, "Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase.", Bioorganic & medicinal chemistry letters, 25, (20), pp. 4405-11
  • James Mutunga, T D Anderson, D T Craft, A D Gross, D R Swale, F Tong, D M Wong, P R Carlier and J R Bloomquist, 2015, "Carbamate and pyrethroid resistance in the akron strain of Anopheles gambiae.", Pesticide biochemistry and physiology, 121, pp. 116-21
  • A Verma, D M Wong, R Islam, F Tong, M Ghavami, James Mutunga, C Slebodnick, J Li, E Viayna, P C Lam, M M Totrov, J R Bloomquist and P R Carlier, 2015, "3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae.", Bioorganic & medicinal chemistry, 23, (6), pp. 1321-40
  • James Mutunga, D R Boina, T D Anderson, J R Bloomquist, P R Carlier, D M Wong, P C Lam and M M Totrov, 2013, "Neurotoxicology of bis(n)-tacrines on Blattella germanica and Drosophila melanogaster acetylcholinesterase.", Archives of insect biochemistry and physiology, 83, (4), pp. 180-94
  • D M Wong, J Li, P C Lam, J A Hartsel, James Mutunga, M Totrov, J R Bloomquist and P R Carlier, 2013, "Aryl methylcarbamates: potency and selectivity towards wild-type and carbamate-insensitive (G119S) Anopheles gambiae acetylcholinesterase, and toxicity to G3 strain An. gambiae.", Chemico-biological interactions, 203, (1), pp. 314-8
  • J A Hartsel, D M Wong, James Mutunga, M Ma, T D Anderson, A Wysinski, R Islam, E A Wong, S L Paulson, J Li, P C Lam, M M Totrov, J R Bloomquist and P R Carlier, 2012, "Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase.", Bioorganic & medicinal chemistry letters, 22, (14), pp. 4593-8
  • D M Wong, J Li, Q H Chen, Q Han, James Mutunga, A Wysinski, T D Anderson, H Ding, T L Carpenetti, A Verma, R Islam, S L Paulson, P C Lam, M Totrov, J R Bloomquist and P R Carlier, 2012, "Select small core structure carbamates exhibit high contact toxicity to "carbamate-resistant" strain malaria mosquitoes, Anopheles gambiae (Akron).", PloS one, 7, (10), pp. e46712
  • H Chen, A K Githeko, J I Githure, James Mutunga, G Zhou and G Yan, 2008, "Monooxygenase levels and knockdown resistance (kdr) allele frequencies in Anopheles gambiae and Anopheles arabiensis in Kenya.", Journal of medical entomology, 45, (2), pp. 242-50

Other

  • E Ogola, J Villinger, D Mabuka, D Omondi, B Orindi, James Mutunga, V Owino and D K Masiga, 2017, "Erratum to: Composition of Anopheles mosquitoes, their blood-meal hosts, and Plasmodium falciparum infection rates in three islands with disparate bed net coverage in Lake Victoria, Kenya.", Malaria journal, 16, (1), pp. 379

Research Projects

Honors and Awards

Service

Service to Penn State:

Service to External Organizations: